![]() ![]() In consequence, it has been demonstrated that the variation in GM might play an important role in the pathogenesis of obesity. Interestingly, the risk of these noncommunicable diseases significantly increases even when a person is only slightly overweight and grows more seriously as the body mass index (BMI) rises. Finally, even some cancers (including endometrial, breast, ovarian, prostate, liver, gallbladder, kidney, and colon cancers) have also been associated with obesity. In accordance to that, since 1980, the rates of diabetes have quadrupled around the world. Furthermore, being obese can also lead to important disorders, including diabetes and its associated conditions and musculoskeletal disorders, such as osteoarthritis. For instance, obesity-associated risk factors have been associated with a large number of chronic diseases, including cardiovascular diseases (e.g., heart disease or stroke), which are the leading causes of death worldwide. Lots of efforts have been devoted to try to decrease the incidence and prevalence, as well as the health complications associated to obesity. Hereby, we propose these metabolites as a metabolic profile associated to a segregated dysbiosis state related to obesity disease. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in o-coumaric acid. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrimination on the different biomarkers in the obesity onset. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. Definite strategies to prevent obesity and related complications remain elusive. Obesity is one of the most incident and concerning disease worldwide. ![]()
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